Background and purpose: Work-related Musculoskeletal Disorders are the most prevalent work- related disorders and the main cause of disability among workers. Also these disorders are the main cause of absence from work and losing work hours and lead to reduction of productivity. Materials & Methods This cross–sectional analytical study was done on 100 workers of Sorak tobacco factory selected randomly. Posture analysis was evaluated by OWAS method and the prevalence of MSDs by Nordic questionnaire. The data was analyzed using EXCEL and SPSS software version 18. Results The workers age mean was (43+-3.97) years OLD and work experience was 12 years. The prevalence of MSDs was 75% in the last year .The limb part (55%), knee (45%) and shoulders (37%) were the most parts of workers’ complaints. WAS posture analysis showed that most postures are critical or need the modification intervention. Conclusion The prevalence of MSDs in Sorak tobacco factory workers is high and the postures are inappropriate. Ergonomic interventional programs as well as educating workers are recommended.