Volume 9, Issue 1 (Winter 2021)                   Iran J Health Sci 2021, 9(1): 1-11 | Back to browse issues page

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Department of Community Health Nursing, Nursing and Midwifery Faculty , m.hosseinzadeh63@gmail.com
Abstract:   (1538 Views)
Background and Purpose
COVID-19 is a new infectious-disease first identified in December 2019 in China, and since it spread globally, it resulted in a Pandemic. Much research is needed to understand the disease, and especially its clinical characteristics. The aim of present study was to explore the clinical features, diagnosis, and treatment of COVID-19 in Tabriz, Iran.
Materials and Methods
This was a case series single center study that focused retrospectively on the clinical characteristics of 140 early consecutive cases with confirmed COVID-19, who were hospitalized at one of the referral hospitals for COVID-19 patients of Tabriz, from March 20 to May 3, 2020. We used patients’ records to obtain the data, which were analyzed by SPSS Version 16 using descriptive and analytic statistics (Student’s t-test, Mann-Whitney’s, and Chi-square test).
Findings showed that 34 out of 140 patients deceased. The highest percentage of patients were in the age range of 65 years and over. The most common symptom on admission was dry-cough (67.9%), followed by shortness of breath (55.7%), and fever (51.5%). During hospitalization, 27.1% showed an increase in white-blood-cell count. Only 20% were ventilated and others received oxygen by cannula, and/or mask. Recovered patients reported significant lower rates of pre-existing comorbid conditions than patients who died (p= .02). 
This single center study with a relatively small sample size showed that the most common symptom on admission among patients with COVID-19 was dry-cough, shortness of breath, and fever. The finding is mostly in accordance with the current evidence seen around the World.
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1. Ottestad W, Søvik S. COVID-19 patients with respiratory failure: what can we learn from aviation medicine?. British journal of anaesthesia. 2020; 125(3): e280-e281. [DOI:10.1016/j.bja.2020.04.012] [PMID] [PMCID]
2. Zhao S, Lin Q. Ran J, Musa SS, Yang G, Wang W,. and et al. Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak. International journal of infectious diseases. 2020; 92: 214-217. [DOI:10.1016/j.ijid.2020.01.050] [PMID] [PMCID]
3. Bogoch II, Watts A, Thomas-Bachli A, Huber C, Kraemer MUG, Khan K. Pneumonia of Unknown Etiology in Wuhan, China: Potential for International Spread Via Commercial Air Travel. Journal of Travel Medicine. 2020 ; 27(2):taaa008. [DOI:10.1093/jtm/taaa008] [PMID] [PMCID]
4. Lu R, Zhao X, Li J and et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020; 395(10224): 565-574. [DOI:10.1016/S0140-6736(20)30251-8]
5. Zhang L, Shen FM, Chen F, Lin Z. Origin and evolution of the 2019 novel coronavirus. Clinical Infectious Diseases, 2020;71(15):882-883. [DOI:10.1093/cid/ciaa112] [PMID] [PMCID]
6. Zhou P, Yang XL, Wang XG and et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579(7798): 270-273. [DOI:10.1038/s41586-020-2012-7] [PMID] [PMCID]
7. Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, and et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020; 395(10223): 507-513. [DOI:10.1016/S0140-6736(20)30211-7]
8. Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Di Napoli R. Features, evaluation and treatment coronavirus (COVID-19), in Statpearls [internet]. 2020, StatPearls Publishing.
9. Zhang J, Litvinova M, Wang W, Wang Y, Deng X, Chen X, and et al. Evolving epidemiology and transmission dynamics of coronavirus disease 2019 outside Hubei province, China: a descriptive and modelling study. The Lancet Infectious Diseases. 2020;20(7):793-802. [DOI:10.1016/S1473-3099(20)30230-9]
10. Singhal T. A review of coronavirus disease-2019 (COVID-19). The Indian Journal of Pediatrics. 2020; 87: 281-286. [DOI:10.1007/s12098-020-03263-6] [PMID] [PMCID]
11. Sharma R, Agarwal M, Gupta M, Somendra S, Saxena SK. Clinical Characteristics and Differential Clinical Diagnosis of Novel Coronavirus Disease 2019 (COVID-19). Coronavirus Disease 2019 (COVID-19). 2020:55-70. [DOI:10.1007/978-981-15-4814-7_6]
12. Shahriarirad R, Khodamoradi Z, Erfani A, Hosseinpour H, Ranjbar K, Emami Y, and et al. Epidemiological and clinical features of 2019 novel coronavirus diseases (COVID-19) in the South of Iran. BMC infectious diseases. 2020; 20(1):427. [DOI:10.1186/s12879-020-05128-x] [PMID] [PMCID]
13. Jalili Khoshnood R, Ommi D, Zali A, Ashrafi F, Vahidi M, Azhide A, and et al. Epidemiological Characteristics, Clinical Features, and Outcome of COVID-19 Patients in Northern Tehran, Iran; a Cross-Sectional Study. Frontiers in Emergency Medicine. 2021; 5(1):e11.
14. Hosseinzadeh Shirayeh B, Shojaie L, Maharatfard Jahromy M, Vaziri M, Safavi S, Jafari R and et al.Comparison of Clinical Characteristics of Hospitalized Patients with and without Covid-19 in Mashhad, Iran: A Retrospective, Single-Center Experiences. International Journal of Pediatrics.2020; 8(12):12619-12628.
15. Kolifarhood G., Aghaali M., Mozafar Saadati H., Taherpour N., Rahimi S., Izadi N., Hashemi Nazari SS. Epidemiological and clinical aspects of COVID-19; a narrative review. Archives of academic emergency medicine. 2020;8(1):e41.
16. Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A. Coronavirus disease 2019 (COVID-19): a systematic review of imaging findings in 919 patients. American Journal of Roentgenology. 2020;215(1):87-93. [DOI:10.2214/AJR.20.23034] [PMID]
17. Lai CC, Liu YH, Wang CY, Wang YH, Hsueh SC, Yen MY, and et al. Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARSCoV-2): Facts and myths. Journal of Microbiology, Immunology and Infection. 2020;53(3): 404-412. [DOI:10.1016/j.jmii.2020.02.012] [PMID] [PMCID]
18. Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? The Lancet. Respiratory Medicine. 2020;8(4):e21. [DOI:10.1016/S2213-2600(20)30116-8]
19. Yang J, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. International Journal of Infectious Diseases. 2020; 94, 91- 95.‏ [DOI:10.1016/j.ijid.2020.03.017] [PMID] [PMCID]
20. Guan WJ, Liang WH, Zhao Y, Liang HR, Chen ZS, Li YM and et al.Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis. European Respiratory Journal. 2020;55(5):2000547. [DOI:10.1183/13993003.00547-2020] [PMID] [PMCID]
21. Tian W, Jiang W, Yao J, Nicholson CJ, Li RH. Sigurslid HH, and et al. Predictors of mortality in hospitalized COVID‐19 patients: A systematic review and meta‐analysis. Journal of medical virology. 2020;92(10):1875-1883. [DOI:10.1002/jmv.26050] [PMID] [PMCID]
22. Jalili M, Payandemehr P, Saghaei A, Sari HN, Safikhani H, Kolivand P. Characteristics and mortality of hospitalized patients with COVID-19 in Iran: a National Retrospective Cohort Study. Annals of internal medicine. 2021;174(1):125-127. [DOI:10.7326/M20-2911] [PMID] [PMCID]
23. Xie J, Tong Z, Guan X, Du B, Qiu H, Slutsky AS. Critical care crisis and some recommendations during the COVID-19 epidemic in China. Intensive care medicine. 2020;46(5):837-840. [DOI:10.1007/s00134-020-05979-7] [PMID] [PMCID]
24. Naicker S, Yang CW, Hwang SJ, Liu BC, Chen JH, Jha V. The Novel Coronavirus 2019 epidemic and kidneys. Kidney International. 2020;97(5):824-828. [DOI:10.1016/j.kint.2020.03.001] [PMID] [PMCID]
25. Iacobucci G. Covid-19: doctors are given new guidelines on when to admit patients to critical care. British Medical Journal. 2020;368:m1189. [DOI:10.1136/bmj.m1189] [PMID]
26. Meng L, Qiu H, Wan L, Ai Y, Xue Z, Guo Q and et al. Intubation and Ventilation amid the COVID-19 OutbreakWuhan's Experience. Anesthesiology. 2020;132(6): 1317-1332. [DOI:10.1097/ALN.0000000000003296] [PMID] [PMCID]
27. Yarahmadi Sh, Etemad K, Hazaveh AM, Azhang N. Urbanization and non-communicable risk factors in the capital city of 6 big provinces of Iran. Iranian journal of public health. 2013; 42(Supple1) ): 113-118.
28. Alamdari NM, Afaghi S, Rahimi FS, Tarki FE, Tavana S, Zali A and et al. Mortality risk factors among hospitalized COVID-19 patients in a major referral center in Iran. The Tohoku Journal of Experimental Medicine. 2020;252(1):73-84. [DOI:10.1620/tjem.252.73] [PMID]
29. Nikpouraghdam M, Jalali Farahani A, Alishiri G, Heydari S, Ebrahimnia M, Samadinia H and et al. Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in IRAN: A single center study. Journal of Clinical Virology. 2020;127:104378. [DOI:10.1016/j.jcv.2020.104378] [PMID] [PMCID]
30. Tabatabaei S, Talari H, Moghaddas F, Rajebi H. CT Features and Short-term Prognosis of COVID-19 Pneumonia: A Single-Center Study from Kashan, Iran. Radiology: Cardiothoracic Imaging. 2020; 2(2): 1-7. [DOI:10.1148/ryct.2020200130] [PMID] [PMCID]
31. Sobhani S, Aryan R, Kalantari E, Soltani S, Malek N, Pirzadeh P and et al. Association between Clinical Characteristics and Laboratory Findings with Outcome of Hospitalized COVID-19 Patients: A Report from Northeast Iran. Interdisciplinary perspectives on infectious diseases.2021; 2021:5552138. [DOI:10.1155/2021/5552138] [PMID] [PMCID]
32. Ganji A, Mosayebi G, Khaki M, Ghazavi A. A Review of the 2019 Novel Coronavirus (Covid-19): Immunopathogenesis, Molecular Biology and Clinical Aspects. Journal of Arak University of Medical Sciences. 2020; 23(1): 8-21. [DOI:10.32598/JAMS.]

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