en بهداشت محیط زیست Environmental Health پژوهشي Original Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><strong>Background and Purpose</strong>: Chronic obstructive pulmonary disease (COPD) is one of the most common chronic diseases that significantly increases the mortality rate. Air pollution is a known risk factor for lung diseases, including asthma and COPD. People who have greater exposure to air pollutants are more likely to develop COPD. This study examined the relationship between particulate matter (PM) and clinical and laboratory diagnostic markers in patients with COPD.<br> <strong>Materials and Methods</strong>: In this cross-sectional analytical study, after obtaining the necessary permits from the medical records department and the hospital information system (HIS), and reviewing the files of patients hospitalized in educational hospitals in Abadan and Khorramshahr cities, Iran, information on 270 patients with COPD was obtained. Information about the amount of PM, from March 21, 2022, to March 20, 2023, was obtained from the Abadan Environment Department. To examine the relationships between PM10 and PM2.5 and clinical and laboratory variables, multiple linear regression analyses were performed. The data were entered into Excel, and the results were analyzed in SPSS.<br> <strong>Results</strong>: The results showed that among laboratory and clinical markers, blood urea nitrogen 22.99&plusmn;13.99 (mg/dL), blood sugar 148.16&plusmn;83.04 (mg/dL), prothrombin time 14.18&plusmn;4.64 (s), alkaline phosphatase 249.49&plusmn;67.21 (IU/L), and erythrocyte sedimentation rate (ESR) 34.47&plusmn;24.22 (mm/h) were higher than the normal mean, and oxygen saturation 90.19&plusmn;8.28% was lower than the normal mean in COPD patients. Also, significant relationships were found between blood sugar (P=0.001), alanine transaminase (P=0.016), and ESR (P=0.039) and PM2.5.<br> <strong>Conclusion</strong>: In patients with COPD, some kidney, liver, and inflammatory laboratory markers were abnormal. A significant association was found between PM and markers such as blood sugar, alanine transaminase, and ESR. Implementing air pollution control measures is vital for the health of these patients, especially on high-pollution days.</span></span></span></div> Pulmonary disease, Particulate matter (PM), Biomarkers 75 84 http://jhs.mazums.ac.ir/browse.php?a_code=A-10-1035-2&slc_lang=en&sid=1 Mohammad Amin Nosrati amin.nosratii77@gmail.com 100319475328460014736 0009-0004-1931-543X No Student Research Committee, Abadan University of Medical Sciences, Abadan, Iran. Hamid Reza Zaheri zaheri_hamidreza@yahoo.com 100319475328460014737 100319475328460014737 No Department of Internal Medicine, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran. Naser Kamyari n.kamyari@yahoo.com 100319475328460014738 100319475328460014738 No Department of Public Health, School of Health, Abadan University of Medical Sciences, Abadan, Iran. Gholamreza Goudarzi rgoodarzy@gmail.com 100319475328460014739 100319475328460014739 No Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Heydar Maleki heydarmaleki72@gmail.com 100319475328460014740 100319475328460014740 No Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Esmat Radmanesh esmatradmanesh33@gmail.com, e.radmanesh@abadanums.ac.ir 100319475328460014741 100319475328460014741 Yes Department of Physiology, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran.