en بهداشت مادر و کودک Maternal and Child Health مروری Review Article <span style="font-size:14px;"><span style="font-family:Tahoma;"><b><span style="color:black">Background and Purpose:</span></b> <span style="color:black">Articaine is a local anesthetic with rapid onset and dual metabolic pathways, making it a potential option for spinal anesthesia in cesarean delivery. However, evidence regarding its efficacy and safety in obstetric anesthesia remains limited. This review aims to summarize current knowledge and assess whether articaine may have a role in cesarean section anesthesia.</span><br> <b><span style="color:black">Materials and Methods:</span></b><span style="color:black"> For this narrative review, a comprehensive literature search was conducted in PubMed, Embase, and Cochrane Library for the period 1995&ndash;2025. Eligible studies included clinical trials, pharmacokinetic investigations, and neurotoxicity assessments examining intrathecal or epidural administration of articaine in both obstetric and non-obstetric populations.</span><br> <b><span style="color:black">Results:</span></b> <span style="color:black">Nine clinical trials and multiple pharmacologic studies were identified. Intrathecal articaine (60&ndash;84 mg, 5% hyperbaric) consistently produced surgical anesthesia within 3&ndash;5 minutes and maintained sensory block for 70&ndash;85 minutes, with earlier motor recovery and ambulation compared to bupivacaine. In obstetric populations, data&mdash;though limited&mdash;demonstrated reliable sensory levels, stable maternal blood pressure, and neonatal Apgar scores comparable to traditional agents. Pharmacokinetic findings revealed a rapid 20&ndash;30 minute plasma half-life due to ester hydrolysis, reducing systemic toxicity risk. No clinically significant neurotoxicity has been reported at cesarean-section doses, though high-dose animal studies indicate the need for ongoing vigilance.</span><br> <b><span style="color:black">Conclusion: </span></b><span style="color:black">Articaine combines fast onset, adequate intraoperative duration, and expedited maternal recovery, making it a promising alternative for spinal anesthesia in cesarean section. However, larger multicenter randomized trials are required to confirm obstetric safety, optimize dosing strategies, and evaluate long-term neonatal outcomes before widespread clinical adoption.</span></span></span><br> &nbsp; Articaine, Cesarean section, Neuraxial block, Spinal anesthesia, Clinical Pharmacokinetics 0 0 http://jhs.mazums.ac.ir/browse.php?a_code=A-10-1207-1&slc_lang=en&sid=1 Iman Asdaghi Jahromi iman.asdaghi@gmail.com 100319475328460015023 100319475328460015023 No Department of Anesthesiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Nafiseh Faghani Makrani dr.nfaghani@gmail.com 100319475328460015022 100319475328460015022 No Department of Anesthesiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Zeinab Babaei Nesami zeinab.babaei@gmail.com 100319475328460015024 0009-0009-2841-0689 No Department of Anesthesiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Keihan Shabankhani kshabankhani@gmail.com 100319475328460015025 100319475328460015025 Yes Department of Anesthesiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.