fa بهداشت Health پژوهشي Original Article <strong>Background:</strong> Crimean-Congo Hemorrhagic Fever (CCHF) is a tick-borne, viral disease that may also be transmitted through person-to-person transmission by exposure to infected body fluids. It causes a severe disease in humans with high mortality rates.<br> <strong>Case presentation:</strong> Here we present two cases of CCHF patients with sudden onset of lethargy, fever, nausea, vomiting, headache, and hemorrhagic manifestation. With one of the patients tick bite was confirmed, then he was treated with ribavirin in isolation and recovered completely. The second patient was in contact with the infected blood of a sheep and, unfortunately, despite the treatment, he passed away.<br> <strong>Conclusion: </strong>Public health measures should focus on preventing this infection by raising the awareness of CCHF symptoms and route of its transmission, and also by adopting practices to decrease the chances of spreading infections in hospitals.<br> &nbsp; Crimean-Congo Hemorrhagic Fever, Abadan, Iran 48 53 http://jhs.mazums.ac.ir/browse.php?a_code=A-10-721-2&slc_lang=fa&sid=1 Ali_Asghar Valipour Aliasgharvalipour698@gmail.com 10031947532846006550 10031947532846006550 No Abadan Faculty of Medical Sciences, Abadan, Iran Azimeh Karimyan karimyanaz@gmail.com 10031947532846006551 10031947532846006551 No Abadan Faculty of Medical Sciences, Abadan, Iran Maghsud Piri maghsudpiri@gmail.com 10031947532846006552 10031947532846006552 No Abadan Faculty of Medical Sciences, Abadan, Iran Dariush Bahrami dariush_bahrami35@yahoo.com 10031947532846006553 10031947532846006553 No Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Fatemeh Hallajian fatemeh.ha9955@gmail.com 10031947532846006554 10031947532846006554 No Abadan Faculty of Medical Sciences, Abadan, Iran Maryam Hezariyan maryamhezarian1996@gmail.com 10031947532846006555 10031947532846006555 No Abadan Faculty of Medical Sciences, Abadan, Iran Mehran Yari normehran2013@yahoo.com 10031947532846006556 10031947532846006556 No Ilam University of Medical Sciences, Ilam, Iran Maziyar Mollaei Pardeh maziyarmollaea@yahoo.com 10031947532846006557 10031947532846006557 No Jundishapur University of Medical Sciences, Ahvaz, Iran Marzieh Ghassemi ghasemimarzie@gmail.com 10031947532846006558 10031947532846006558 Yes Tehran University of Medical Sciences, Tehran, Iran