Iranian Journal Of Health Sciences

en Co-morbidity of Diabetes and Tuberculosis Can Affect the Results of Treatment; A Case Control Study in Iran اپيدميولوژي Epidemiology پژوهشي Original Article <div style="text-align: justify;">Background and Purpose: Several evidences have shown some synergistic effect of diabetes co-morbidity on the tuberculosis (TB) treatment results, while some other studies have not found such associations. This study aimed to investigate the relationship between TB-diabetes co-morbidity and outcomes of TB treatment. Materials and Methods: The research population in this case control study were patients with smear positive tuberculosis. The cases were 158 patients with TB and diabetes selected by consensus method, while controls were 316 patients randomly selected from TB patients without diabetes. Results: Frequency of unfavorable outcome among cases was higher than among controls (7.6% vs 7.3% respectively, p-value =0.901). Multivariate logistic regression models showed that the odds ratios for adverse treatment outcome, death, treatment failure, positive smear after the intensive phase of treatment and high grade positivity (2+ & 3+) were 0.97(0.45- 2.06), 0.97(0.42-2.24), 0.91(0.17-4.85), 1.39(0.79- 2.44) and 2.57(0.83- 7.92) respectively. Moreover, treatment adverse outcomes among patients with drug complications (22.2% vs. 6.5%, p-value =0.010) and rural residents (10% vs 4.9% respectively, p-value =0.037) were significantly higher than those among patients without complication and urban residents respectively. Conclusion: Although we did not observe any significant association between TB-diabetes co-morbidity and treatment results, there was a significant effect measure regarding the effect of smear positivity at the end of the intensive phase of treatment, especially high grade of smear positivity. Because of probable bias in the classification of the exposure, screening of TB patients regarding diabetes mellitus at the beginning of the treatment is recommended.</div> Tuberculosis, Diabetes, Death, Treatment Failure 24 31 http://jhs.mazums.ac.ir/browse.php?a_code=A-10-478-7&slc_lang=en&sid=1 Mahdi Afshari مهدی افشاری mahdiafshari99@gmail.com 10031947532846008870 10031947532846008870 No Pediatric Gastroenterology and Hepatology Research Center Motahareh Kheradmand مطهره خردمند elham.kherad@gmail.com 10031947532846008871 10031947532846008871 No Health Sciences Research Center, Addiction Institute Mohsen Aarabi مخسن اعرابی mohsen.aarabi@gmail.com 10031947532846008872 10031947532846008872 No Department of Family Medicine Mohammadreza Parsaee مخمدرضا پارسایی mrparsaie@gmail.com 10031947532846008873 10031947532846008873 No Health deputy Fatemeh Roozbeh فاطمه روزبه fatemehroozbeh@gmail.com 10031947532846008874 10031947532846008874 No Health deputy Asghar Nezammahalleh اصغر نظام محله asnezam14@gmail.com 10031947532846008875 10031947532846008875 No Health deputy Keyvan Heydari کیوان حیدری kvan3787@gmail.com 10031947532846008876 10031947532846008876 No Student Research Committee, School of Medicine, Maryam Zakian مریم زکیان m.zakian@mazust.ac.ir 10031947532846008877 10031947532846008877 No Department of General Courses, Mahmood Moosazadeh محمود موسی زاده mmoosazadeh1351@gmail.com 10031947532846008878 10031947532846008878 Yes Gastrointestinal Cancer Research Center, Non -communicable Diseases Institute