en اپيدميولوژي Epidemiology پژوهشي Original Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><span style="unicode-bidi:embed"><span new="" roman="" times=""><strong>Background and Purpose</strong>: Numerous comorbidities are involved in the severity of the new coronavirus disease 2019 (COVID-19). Hypothyroidism&rsquo;s impact on COVID-19 is yet to be adequately understood. Thyroid disorders are thought to play a role in the development and progress of COVID-19. This study aimed to determine the frequency of hypothyroidism among COVID-19 patients in hospitalized patients.<br> <strong>Materials and Methods</strong>: This retrospective cross-sectional study was conducted at a tertiary hospital in Tehran City, Iran. Demographic information and other specified data related to our research, mainly comorbidities, were collected using a structured questionnaire from electronic patient health records. A total of 493 medical records of COVID-19 patients were used for this study according to the inclusion criteria. Subsequently, the data were analyzed with SPSS, version 25, using descriptive and analytic statistics.<br> <strong>Results</strong>: The prevalence of hypothyroidism was 13.2% (n=65) in hospitalized COVID-19 patients. This was higher (13.4% vs 2.3%) compared with the prevalence of hypothyroidism in the general Iranian population. Overall, in patients with hypothyroidism, about 21 patients (32.3%) expired, of whom 14 patients (66.7%) were female, and 7 (33.3%) were male. In these patients, no statistically significant difference was observed between the expired and discharged groups (Adjusted Odds Ratio: 1.04; 95% CI 0.59-1.83; P=0.87). As a result, hypothyroidism was not linked to an increased risk of death.<br> <strong>Conclusion</strong>: Hypothyroidism in hospitalized COVID-19 patients appears to be low. However, it seems more prevalent in the female gender but without significant adverse effects on the risk of mortality from this disease.&nbsp;</span></span></span></span></span></div> <div> <div> <div class="msocomtxt" id="_com_1" language="JavaScript" on="" style="text-align: justify;"><illegal tag=""><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><span lang="FA" dir="RTL" style="font-family:"Arial",sans-serif"></span></span></span></span></illegal></div> </div> </div> COVID-19, Prevalence, Hypothyroidism, Comorbidities  87 92 http://jhs.mazums.ac.ir/browse.php?a_code=A-10-942-1&slc_lang=en&sid=1 Fatemeh Esfahanian فاطمه اصفهانیان fesfahanian@sina.tums.ac.ir 10031947532846009748 10031947532846009748 No Department of Endocrinology, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Seyed Ahmad SeyedAlinaghi سید احمد سیدعلی نقی s_a_alinaghi@yahoo.com 10031947532846009749 10031947532846009749 No Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran. Nazanin Janfaza نازنین جانفازا n.janfaza@gmail.com 10031947532846009750 10031947532846009750 No Department of Endocrinology, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Marcarious Moorkereh Tantuoyir مارکاریوس تانتوییر macasty1234@gmail.com 10031947532846009751 10031947532846009751 Yes Department of Internal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.