en بيماريهاي مغز و اعصاب (نورولوژی) Neurology مروری Review Article <div style="text-align: justify;"><strong>Background and Purpose</strong>: Spasticity is a disabling complication of spinal cord injury (SCI). The administration of various medications is not satisfactory. Studies show the effects of onabotulinumtoxinA treatment for spasticity in patients with SCI. We designed this study to systematically review the effects of onabotulinumtoxinA toxin on spasticity status in patients with SCI.<br> <strong>Materials and Methods</strong>: PubMed, Scopus, EMBASE, Web of Science, Google Scholar, and gray literature, including references and conference abstracts, were systematically searched by two researchers published before September 2023. Data regarding the total number of participants, first author, publication year, country of origin, mean age, follow-up time, the site of injection, main findings, and side effects were extracted and recorded.<br> <strong>Results</strong>: A literature search revealed 2914 articles. After deleting duplicates, 1688 remained. After careful evaluation of the full texts, six articles remained. Two studies reported improvement in the modified Ashworth scale after treatment, while one showed opposite results. Improvement of spasticity and spasticity-related pain was observed in one study, and a decrease in the modified Tardieu scale was found in another study. Improvement in upper-extremity function, positioning, and pain after treatment was shown in a study done in the USA.<br> <strong>Conclusion</strong>: The results of this systematic review show that administration of onabotulinumtoxinA toxin may improve spasticity in patients with SCI.</div> Spinal cord injury (SCI), Spasticity, Botulinum toxins, Type A 65 74 http://jhs.mazums.ac.ir/browse.php?a_code=A-10-1038-1&slc_lang=en&sid=1 Maryam Hosseini مریم حسینی m_hosseini100@yahoo.com 100319475328460012428 100319475328460012428 No Department of Physical Medicine and Rehabilitation, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. بیمارستان امام خمینی، دانشگاه علوم پزشکی تهران، تهران، ایران Saeed Vaheb سعید واهب saeedvaheb.sv@gmail.com 100319475328460012429 100319475328460012429 No Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. مرکز تحقیقات علوم اعصاب اصفهان، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران Mohaddeseh Azadvari محدثه آزادواری drazadvari@yahoo.com 100319475328460012430 100319475328460012430 No Department of Physical Medicine and Rehabilitation, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. بیمارستان سینا و امام خمینی، دانشگاه علوم پزشکی تهران، تهران، ایران Mohsen Rastkar محسن راستکار rastkar@gmail.com 100319475328460012431 100319475328460012431 No Student’s Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. مرکز تحقیقات علمی دانشجویی، دانشگاه علوم پزشکی تهران، تهران، ایران Mahsa Ghajarzadeh مهسا قجرزاده m.ghajarzadeh@gmail.com 100319475328460012432 100319475328460012432 No Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran شورای جهانی اپیدمیولوژی (UCE)، شبکه جهانی آموزش و تحقیقات علمی (USERN)، دانشگاه علوم پزشکی تهران، تهران، ایران Maryam Cheraghali مریم چراغعلی dr.mcheraghali@gmail.com 100319475328460012433 0009-0006-2066-8106 No Department of Physical Medicine and Rehabilitation, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. بیمارستان امام خمینی، دانشگاه علوم پزشکی تهران، تهران، ایران Seyede Zahra Emami Razavi سیده زهرا امامی رضوی zemamirazavi@gmail.com 100319475328460012434 100319475328460012434 Yes Joint Reconstruction Research Center, Tehran University of Medical Sciences, Tehran, Iran. مرکز تحقیقات تعویض مفاصل، دانشگاه علوم پزشکی تهران، تهران، ایران