en بهداشت خانواده Family Health پژوهشي Original Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><strong>Background and Purpose</strong>: Hypertension is a major medical condition that can cause many complications and sudden death when not appropriately controlled. This study determined serum calcium, parathyroid hormone, vitamin D, renin, angiotensin II, angiotensin I converting enzyme, and aldosterone in hypertensive individuals, as these compounds play key roles in regulating human blood pressure.&nbsp;<br> <strong>Materials and Methods</strong>: This case-control study was conducted on 549 (324 hypertensive cases and 225 controls) individuals between October 2018 and September 2020. Fasting blood samples were collected into plain vacutainer bottles to determine serum calcium, parathyroid hormone, vitamin D, and renin-angiotensin components using ion selective electrode and ELISA methods. Continuous and categorical variables were subjected to appropriate statistical analyses using the STATA version 16 (StataCorp LLC).<br> <strong>Results</strong>: The demographic comparison showed that the mean age did not differ between the case and control groups, but the body mass index was higher (P<0.05) among the case group. The mean calcium value was elevated in the case group (2.41&plusmn;0.26 mmol/L) vs the control group (2.20&plusmn;0.54 mmol/L) (P<0.001). Comparing between case and control groups, the median values of parathyroid hormone (PTH) (47.26 pg/mL, interquartile range [IQR]=25.05-71.70 vs 26.43 pg/mL, IQR=17.67-45.70) (P<0.001), renin (339.77 pg/mL, IQR=227.61-566.89 vs pg/mL 269.295, IQR=159.30-420.13) (P<0.001), angiotensin II (402.74 pg/mL, IQR=253.79-594.77 vs 328.19 pg/mL, IQR=264.24-383.51) (P<0.001), angiotensin I converting enzyme (3.13 ng/mL, IQR=1.77-7.35 vs 1.82 ng/mL, IQR=1.25-3.58) (P<0.001), and aldosterone (307.18 pg/mL, IQR=204.05-502.32 vs 187.85 pg/mL, IQR=163.89-306.13) (P<0.001) were higher in the hypertensive group. However, Vitamin D (42.91 nmol/L, IQR=24.32-55.48 vs 55.33 nmol/L, IQR=42.67-99.73) was reduced (P<0.001) among hypertensive individuals. Multivariate analysis showed that increase in calcium (odds ratio=5.012, P<0.001; 95% CI, 2.885%, 8.707%, PTH (odds ratio=1.0204; P<0.001; 95% CI, 1.0139%, 1.02699%) and aldosterone (odds ratio=1.0008; P=0.001; 95% CI, 1.00032%, 1.00129%) were related with higher odds of hypertension and its associated complications.&nbsp;<br> <strong>Conclusion</strong>: Abnormal parathyroid, vitamin D, aldosterone hormones, and calcium were associated with pathophysiology and prominence of hypertension.</span></span></span></div> Hypertension, Parathyroid hormone, Vitamin D, Renin-angiotensin-aldosterone system (RAAS) 195 204 http://jhs.mazums.ac.ir/browse.php?a_code=A-10-1050-2&slc_lang=en&sid=1 Oloruntoba Ayodele Ekun ayodele1619.oe@gmail.com 100319475328460011819 100319475328460011819 Yes Department of Medical Laboratory Science, College of Medicine University of Lagos, Lagos, Nigeria. Oyeronke Olufemi Ekun oyeronke.olufemi@gmail.com 100319475328460011820 100319475328460011820 No Department of Medical Laboratory Science, College of Medicine University of Lagos, Lagos, Nigeria. Oseni Mosesa oenimoses01@gmail.com 100319475328460011821 0009-0005-6965-4218 No Department of Medical Laboratory Science, College of Medicine University of Lagos, Lagos, Nigeria. Folasade Adeola Daniel dansade2892@gmail.com 100319475328460011822 100319475328460011822 No Department of Medicine, Lagos State University Teaching Hospital, Lagos State University, Lagos, Nigeria. Olayiwola Akannji Popoola olapopoola@unilag.edu.ng 100319475328460011823 100319475328460011823 No Department of Medical Laboratory Science, College of Medicine University of Lagos, Lagos, Nigeria. Nkeruka Ogochukwu Ogidi udegbunamn32@yahoo.com 100319475328460011824 0009-0004-4839-4413 No Department of Medical Laboratory Science, College of Medicine University of Lagos, Lagos, Nigeria. Falilat Funke Ogundarec funke.ogundare@lasucom.edu.ng 100319475328460011825 100319475328460011825 No Department of Chemical Pathology, College of Medicine, Lagos State University, Lagos, Nigeria. Oluyemi Akinloye oakinloye@unilag.edu.ng 100319475328460011826 100319475328460011826 No Department of Medical Laboratory Science, College of Medicine University of Lagos, Lagos, Nigeria.