Volume 3, Number 4 (Autumn 2015)                   Iran J Health Sci 2015, 3(4): 24-32 | Back to browse issues page



DOI: 10.7508/ijhs.2015.04.003

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Parvareh M, Khanjani N, Frahmandinia Z, Nouri B. The Survival Rate of Childhood Leukemia and Its Related Factors in Kerman, Iran. Iran J Health Sci. 2015; 3 (4) :24-32
URL: http://jhs.mazums.ac.ir/article-1-344-en.html

Associate Professor, Department of Epidemiology and Biostatistic, School of Health, Kerman University of Medical Sciences, Kerman, Iran Department of Epidemiology and Biostatistic, School of Health, Kerman University of Medical Sciences, Kerman, Iran
Abstract:   (813 Views)

Background and Purpose: Leukemia is the most prevalent type of cancer in children and its
prognostic factors vary in different geographic locations. The aim of this study was to estimate
the 5 years survival rate of children suffering from leukemia in Kerman, Iran and to investigate
the factors which might influence it.
Materials and Methods: This was a cohort study conducted on patients with acute
lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Cases were all younger
than 15 years old admitted to Afzalipour Hospital, Kerman, Iran between 1998 and 2009, and
included 219 patients. Survival rates were estimated by applying the Kaplan–Meier method.
Log-rank test was used to estimate the statistical difference in survival probability and the effect
of independent variables on survival was examined using Cox regression. All analyses were
performed using STATA-12.
Results: The cumulative 5 years rate of survival in this study was 58% and 43% for ALL and
AML, respectively, and the difference was statistically significant (P = 0.0030). Multivariate
Cox regression analysis showed that white blood cell (WBC) &ge 50,000 &mul (P = 0.0100) and
relapse (P = 0.0060) of ALL patients has a significant effect on survival. In AML due to the
small number of patients significant results were not achieved. The cumulative survival rate at
the end of 1 year for low, medium and high-risk patients were estimated 97%, 94%, and 78%.
Conclusion: Leukemia patients with and WBC &ge 50,000 &mul and a history of relapse had less
survival.

Full-Text [PDF 124 kb]   (430 Downloads)    
Type of Study: Original Article | Subject: Health
Received: 2015/11/21 | Accepted: 2015/11/21 | Published: 2015/11/21

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