Volume 4, Number 2 (Spring 2016)                   Iran J Health Sci 2016, 4(2): 43-48 | Back to browse issues page



DOI: 10.18869/acadpub.jhs.4.2.43

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Fayyaz-Movaghar A, Kamel-Mirmostafaee M T, Borhani T S. Probability Model of Allele Frequency of Alzheimer’s Disease Genetic Risk Factor . Iran J Health Sci. 2016; 4 (2) :43-48
URL: http://jhs.mazums.ac.ir/article-1-413-en.html

University of Mazandaran, Babolsar, Iran
Abstract:   (800 Views)

Background and Purpose: The identification of genetics risk factors of human diseases is very important. This study is conducted to model the allele frequencies (AFs) of Alzheimer’s disease.

Materials and Methods: In this study, several candidate probability distributions are fitted on a data set of Alzheimer’s disease genetic risk factor. Unknown parameters of the considered distributions are estimated, and some criterions of goodness-of-fit are calculated for the sake of comparison.

Results: Based on some statistical criterions, the beta distribution gives the best fit on AFs. However, the estimate values of the parameters of beta distribution lead us to the standard uniform distribution.

Conclusion: The AFs of Alzheimer’s disease follow the standard uniform distribution.

Full-Text [PDF 742 kb]   (492 Downloads)    
Type of Study: Original Article | Subject: Biostatistics
Received: 2016/06/26 | Accepted: 2016/06/26 | Published: 2016/06/26

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