Volume 6, Issue 1 (Winter 2018)
Iran J Health Sci 2018, 6(1): 25-32 |
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Ramzani Ghara A, Ezzati Ghadi F. Effect of Purslane on Kidney Failure Following Copper Toxicity in a Rat Model. Iran J Health Sci 2018; 6 (1) :25-32
URL: http://jhs.mazums.ac.ir/article-1-541-en.html
URL: http://jhs.mazums.ac.ir/article-1-541-en.html
Department of Plant Biology, University of Jiroft, Jiroft, Kerman
Abstract: (6950 Views)
Background and purpose: Copper (Cu) is an essential trace element. The toxic level of copper can catalyze the formation of free radicals which cause various diseases including kidney failure. The main aim of this study was to evaluate the effects of purslane on kidney failure due to copper toxicity in rat model.
Materials and Methods: Twenty-eight male Wistar rats were divided equally and randomly into four groups. Group I was control group, while in group II, copper sulphate was administrated orally in dose of 200 mg/kg body weight every day for one month. In group III, on the other hand, purslane was orally given in a dose of 400 mg/kg body weight per day for one month. Group IV received combined treatment of copper sulphate and pursalne as described in groups II and III. Blood urea nitrogen (BUN) and serum creatinine was then measured. The kidney tissues were subject to histopathological study.
Results: The results showed that serum BUN and creatinine were increased in the copper-treated rat which were 52/20± 4/91 and 0/56± 0/06, respectively. Purslane administration also decreased the elevated level of creatinine and BUN in rats which received toxic levels of copper (0/48± 0/03 and 44/80± 5/7, respectively).
Conclusion: The present study revealed that purslane improved some kidney function parameters due to its antioxidant and anti-inflammatory properties.
Materials and Methods: Twenty-eight male Wistar rats were divided equally and randomly into four groups. Group I was control group, while in group II, copper sulphate was administrated orally in dose of 200 mg/kg body weight every day for one month. In group III, on the other hand, purslane was orally given in a dose of 400 mg/kg body weight per day for one month. Group IV received combined treatment of copper sulphate and pursalne as described in groups II and III. Blood urea nitrogen (BUN) and serum creatinine was then measured. The kidney tissues were subject to histopathological study.
Results: The results showed that serum BUN and creatinine were increased in the copper-treated rat which were 52/20± 4/91 and 0/56± 0/06, respectively. Purslane administration also decreased the elevated level of creatinine and BUN in rats which received toxic levels of copper (0/48± 0/03 and 44/80± 5/7, respectively).
Conclusion: The present study revealed that purslane improved some kidney function parameters due to its antioxidant and anti-inflammatory properties.
Type of Study: Original Article |
Subject:
Health
References
1. Eapen S, D'souza SF. Prospects of genetic engineering of plants for phytoremediation of toxic metals. Biotechnology Advances. 2005;23(2):97–114. [DOI:10.1016/j.biotechadv.2004.10.001] [PMID]
2. Kavamura VN, Esposito E. Biotechnological strategies applied to the decontamination of soils polluted with heavy metals. Biotechnology Advances. 2010;28(1):61–9. [DOI:10.1016/j.biotechadv.2009.09.002] [PMID]
3. Miransari M. Hyperaccumulators, arbuscular mycorrhizal fungi and stress of heavy metals. Biotechnology Advances. 2011;29(6):645–53. [DOI:10.1016/j.biotechadv.2011.04.006] [PMID]
4. Yang X, Feng Y, He Z, Stoffella PJ. Molecular mechanisms of heavy metal hyperaccumulation and phytoremediation. Journal of Trace Element Medical Biology. 2005;18(4):339–53. [DOI:10.1016/j.jtemb.2005.02.007] [PMID]
5. Foyer CH, Halliwell B. The presence of glutathione and glutathione reductase in chloroplasts: a proposed role in ascorbic acid metabolism. Planta. 1976;133(1):21–5. [DOI:10.1007/BF00386001] [PMID]
6. Sharma SS, Dietz K-J. The relationship between metal toxicity and cellular redox imbalance. Trends Plant Science. 2009;14(1):43–50. [DOI:10.1016/j.tplants.2008.10.007] [PMID]
7. Hossain MA, Piyatida P, da Silva JAT, Fujita M. Molecular mechanism of heavy metal toxicity and tolerance in plants: central role of glutathione in detoxification of reactive oxygen species and methylglyoxal and in heavy metal chelation. Journal of Botany. 2012;2012.
8. Burke J, Handy RD. Sodium-sensitive and-insensitive copper accumulation by isolated intestinal cells of rainbow trout Oncorhynchus mykiss. Journal of Experimental Biology. 2005;208(2):391–407. [DOI:10.1242/jeb.01379] [PMID]
9. Valko M, Jomova K, Rhodes CJ, Kuča K, Musílek K. Redox-and non-redox-metal-induced formation of free radicals and their role in human disease. Arch Toxicol. 2016;90(1):1–37. [DOI:10.1007/s00204-015-1579-5] [PMID]
10. Kumar V, Kalita J, Misra UK, Bora HK. A study of dose response and organ susceptibility of copper toxicity in a rat model. Journal of Trace Elemental Medical Biology. 2015;29:269–74. [DOI:10.1016/j.jtemb.2014.06.004] [PMID]
11. Y Aboul-Enein H, Berczynski P, Kruk I. Phenolic compounds: the role of redox regulation in neurodegenerative disease and cancer. Mini Review Medical Chemistry. 2013;13(3):385–98.
https://doi.org/10.2174/1389557511313030007 [DOI:10.2174/138955713804999766]
12. Gangwar M, Gautam MK, Sharma AK, Tripathi YB, Goel RK, Nath G. Antioxidant capacity and radical scavenging effect of polyphenol rich Mallotus philippenensis fruit extract on human erythrocytes: an in vitro study. Science World Journal. 2014;2014.
13. Huang Z, Wang B, Eaves DH, Shikany JM, Pace RD. Phenolic compound profile of selected vegetables frequently consumed by African Americans in the southeast United States. Food Chemistry. 2007;103(4):1395–402. [DOI:10.1016/j.foodchem.2006.10.077]
14. Yazici I, Türkan I, Sekmen AH, Demiral T. Salinity tolerance of purslane (Portulaca oleracea L.) is achieved by enhanced antioxidative system, lower level of lipid peroxidation and proline accumulation. Environmental Exp Bot. 2007;61(1):49–57. [DOI:10.1016/j.envexpbot.2007.02.010]
15. Uddin MK, Juraimi AS, Hossain MS, Nahar MAU, Ali ME, Rahman MM. Purslane weed (Portulaca oleracea): a prospective plant source of nutrition, omega-3 fatty acid, and antioxidant attributes. Science World Journal. 2014;2014.
16. Liang X, Li L, Tian J, Wu Y, Gao P, Li D, et al. A rapid extraction and analysis method for the simultaneous determination of 26 bioflavonoids in Portulaca oleracea L. Phytochemistry Analysis. 2014;25(6):537–43. [DOI:10.1002/pca.2524] [PMID]
17. Kumar V, Kalita J, Bora HK, Misra UK. Relationship of antioxidant and oxidative stress markers in different organs following copper toxicity in a rat model. Toxicology and Applied Pharmacology. 2016;293:37–43. [DOI:10.1016/j.taap.2016.01.007] [PMID]
18. Gong F, Li F, Zhang L, Li J, Zhang Z, Wang G. Hypoglycemic effects of crude polysaccharide from purslane. International Journal of Mollecular Science. 2009;10(3):880–8. [DOI:10.3390/ijms10030880] [PMID] [PMCID]
19. Humanson GL. Basic procedures—animal tissue technique. Animal tissue techniques. WH Freeman & Co., San Francisco; 1961.
20. Gooneratne SR, Howell JM, Aughey E. An ultrastructural study of the kidney of normal, copper poisoned and thiomolybdate-treated sheep. Journal of Comparative Pathology. 1986;96(6):593–612. [DOI:10.1016/0021-9975(86)90057-5]
21. Roberts EA, Schilsky ML. Diagnosis and treatment of Wilson disease: an update. Hepatology. 2008;47(6):2089–111. [DOI:10.1002/hep.22261] [PMID]
22. Babaknejad N, Moshtaghie AA, Shahanipour K. The Toxicity of Copper on Serum Parameters Related to Renal Functions in Male Wistar Rats. Zahedan Journal of Research Medical Science. 2015;15.
23. Amiri A, Ramzani Ghara A, Ezzati Ghadi F, Rezaei Zarchi S. Evaluation effect of purslane (portulaca oleracea) on copper sulphate induced hepatic necrosis in rats. Iran Journal of Medical Aromatic Plants. 2017;32(2).
24. Pal A, Badyal RK, Vasishta RK, Attri SV, Thapa BR, Prasad R. Biochemical, histological, and memory impairment effects of chronic copper toxicity: a model for non-Wilsonian brain copper toxicosis in Wistar rat. Biological Trace Element Research. 2013;153(1–3):257–68. [DOI:10.1007/s12011-013-9665-0] [PMID]
25. Ezzati Ghadi F, Ramezani Ghara A, Amiri A, Rezaei-Zarch S. Modulation of Fourier Transform Infrared Spectra and Copper Levels by Purslane (Portulaca Oleracea) Against Liver Necrosis Induced by Copper Sulphate. Biomacromolecular Journal. 2016;2(1):78–85.
26. Kim JW, Yang H, Cho N, Kim B, Kim YC, Sung SH. Hepatoprotective constituents of Firmiana simplex stem bark against ethanol insult to primary rat hepatocytes. Pharmacognocy Magazine. 2015;11(41):55. [DOI:10.4103/0973-1296.149704] [PMID] [PMCID]
27. Lucarini R, Bernardes WA, Tozatti MG, da Silva Filho AA, Silva MLAE, Momo C, et al. Hepatoprotective effect of Rosmarinus officinalis and rosmarinic acid on acetaminophen-induced liver damage. Emirates Journal of Food Agricalture. 2014;26(10):878. [DOI:10.9755/ejfa.v26i10.17836]
28. Sinkovič A, Strdin A, Svenšek F. Severe acute copper sulphate poisoning: a case report. Arhiv za Higijenu Rada Toksikolgiju. 2008 Mar;59(1):31-5. [DOI:10.2478/10004-1254-59-2008-1847] [PMID]
29. Galhardi CM, Diniz YS, Faine LA, Rodrigues HG, Burneiko RCM, Ribas BO, et al. Toxicity of copper intake: lipid profile, oxidative stress and susceptibility to renal dysfunction. Food Chemistry Toxicology. 2004;42(12):2053–60. [DOI:10.1016/j.fct.2004.07.020] [PMID]
30. Simopoulos AP. Omega-3 fatty acids and antioxidants in edible wild plants. Biological Research. 2004;37(2):263–77. [DOI:10.4067/S0716-97602004000200013] [PMID]
31. Simopoulos AP. Omega-3 fatty acids in health and disease and in growth and development. The American Journal of Clinical Nutrition. 1991;54(3):438–63. [DOI:10.1093/ajcn/54.3.438] [PMID]
32. Xin HL, Xu YF, Yue XQ, Hou YH, Li M, Ling CQ. Analysis of chemical constituents in extract from Portulaca oleracea L. with GC-MS method. Pharmacology Journal of Chinies People's Lib Army. 2008;24:133–6.
33. Hozayen W, Bastawy M, Elshafeey H. Effects of aqueous purslane (Portulaca oleracea) extract and fish oil on gentamicin nephrotoxicity in albino rats. National Science. 2011;9(2):47–62.
34. chowdhary cv, meruva a, elumalai rka. a review on phytochemical and pharmacological profile of portulaca oleracea linn.(purslane). international journal of research ayurveda pharmcy. 2013;4(1).
35. Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols: food sources and bioavailability. The American Journal of Clinical Nutrition. 2004;79(5):727–47. [DOI:10.1093/ajcn/79.5.727] [PMID]
36. Lopez-Velez M, Martinez-Martinez F, Valle-Ribes C Del. The study of phenolic compounds as natural antioxidants in wine. critical reviews in food science and nutrition. 2003;43(3):233-44.
https://doi.org/10.1080/727072831 [DOI:10.1080/10408690390826509] [PMID]
37. Eidi A, Mortazavi P, Moghadam JZ, Mardani PM. Hepatoprotective effects of Portulaca oleracea extract against CCl4-induced damage in rats. Pharmaceutical Biology. 2015;53(7):1042–51. [DOI:10.3109/13880209.2014.957783] [PMID]
38. Priyamvada S, Priyadarshini M, Arivarasu NA, Farooq N, Khan S, Khan SA, et al. Studies on the protective effect of dietary fish oil on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney. Prostaglandins, Leukot Essent Fat Acids. 2008;78(6):369–81. [DOI:10.1016/j.plefa.2008.04.008] [PMID]
39. Karimi G, Khoei A, Omidi A, Kalantari M, Babaei J, Taghiabadi E, et al. Protective effect of aqueous and ethanolic extracts of Portulaca oleracea against cisplatin induced nephrotoxicity. Iranian Journal of Basic Medical Sciences. 2010;13(2):31–5.
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