Volume 7, Issue 3 (Summer 2019)                   Iran J Health Sci 2019, 7(3): 51-56 | Back to browse issues page

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Karami F, Mohammadian M, Mahdavi S A, Rahimi M T. The ABO Blood Group System and Plasmodium Infection in Iran: A Comprehensive Study. Iran J Health Sci. 2019; 7 (3) :51-56
URL: http://jhs.mazums.ac.ir/article-1-655-en.html
Mazandaran University of Medical Sciences, Sari, Iran , sa.mahdavi@mazums.ac.ir
Abstract:   (545 Views)
Background: Geographical distribution of ABO blood groups affects by race, ethnicity, migration and some infectious agents, such as Plasmodium species. P. falciparum is the major causative agent of death in malaria that can affect ABO blood group distribution in different populations. Therefore, the objective of the current study was to determine the effect of p. falciparum on ABO blood group distribution in Iran.
Methods: The present study was conducted on the database of Iranian Blood Transfusion Organization (IBTO) in 30 provinces of the country about ABO and Rh blood groups of the people who referred to health centers from June 2011 to August 2012.  
Results: A total number of 2124560 individuals were referred to IBTO in 30 provinces. The highest and lowest rates of O blood group were observed in Sistan & Baluchestan (64.6%) and Lorestan (37.7%), respectively. P. falciparum was the most common species of malaria in Sistan & Baluchestan (53215) and the rarest infection agent in Semnan province (20). The results showed statistically significant relationship (p < 0.05) between prevalence of P. falciparum with O blood group, while this relationship for A blood group was not significant (p > 0.05).
Conclusion: Our results revealed a significant relationship between prevalence of P. falciparum and geographical distribution of ABO blood. There was also found more susceptibility and risk to malaria infection and cerebral malaria in A blood group compared to other groups. In addition, this was the first comprehensive study on the ABO blood group system and Plasmodium infection in Iran.
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Type of Study: Original Article | Subject: Community Health

1. Pourfath A, Oody A, Honarkaran N. Geographical distribution of ABO and Rh (D) blood groups among Iranian blood donors in the year (1982) as compared with that of the year 2001. Blood (Khoon). 2001; 1 (1): 11-17.
2. Cserti CM, Dzik WH. The ABO blood group system and Plasmodium falciparum malaria. Blood. 2007; 110 (7): 2250-2258. [DOI:10.1182/blood-2007-03-077602] [PMID]
3. Uneke CJ. Plasmodium falciparum malaria and ABO blood group: is there any relationship?. Parasitology Research. 2007; 100 (4): 759-765. [DOI:10.1007/s00436-006-0342-5] [PMID]
4. 4. Mahdavi SA, Raeesi A, Faraji L, Youssefi MR, Rahimi MT. A case of misdiagnose of malaria infection. Asian Pacific Journal of Tropical Biomedicine. 2013; 3 (9): 748-750. [DOI:10.1016/S2221-1691(13)60150-1]
5. Mahdavi SA, Raeesi A, Faraji L, Youssefi MR, Rahimi MT. Malaria or flu? A case report of misdiagnosis. Asian Pacific Journal of Tropical Biomedicine. 2014; 31(4): 56-58. [DOI:10.12980/APJTB.4.2014C932] [PMID] [PMCID]
6. Youssefi MR, Rahimi MT. Prevalence of malaria infection in Sarbaz, Sistan and Bluchistan province. Asian Pacific Journal of Tropical Biomedicine. 2011; (1) 6: 491-492. [DOI:10.1016/S2221-1691(11)60107-X]
7. Rowe JA, Handel IG, Thera MA. Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting. Proceedings of the National Academy of Sciences. 2007; 104 (44): 17471-17476. [DOI:10.1073/pnas.0705390104] [PMID] [PMCID]
8. Gupte SC, Patel AG, Patel TG. Association of ABO groups in malaria infection of variable severity. Journal of Vector Borne Disease. 2012; 49 (2):78-81.
9. Alwar VA, Rameshkumar K, Ross C. ABO blood groups and malaria related clinical outcome. Journal of Vector Borne Disease. 2011; 48 (1): 7-13.
10. Tekeste Z, Petros B. The ABO blood group and Plasmodium falciparum malaria in Awash, Metehara and Ziway areas, Ethiopia. Malaria Journal. 2010; 9 (3): 280-285. [DOI:10.1186/1475-2875-9-280] [PMID] [PMCID]
11. Fry AE, Griffiths MJ, Auburn S. Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria. Human Molecular Gen. 2008; 17(4): 567-576. [DOI:10.1093/hmg/ddm331] [PMID] [PMCID]
12. Miller LH, Baruch DI, Marsh K. The pathogenic basis of malaria. Nature. 2002; 415 (6872): 673-679. [DOI:10.1038/415673a] [PMID]

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