Volume 9, Issue 1 (Winter 2021)                   Iran J Health Sci 2021, 9(1): 35-44 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ghaffari J, dabaghzadeh A, Ghaffari N. Comorbidities in Patients with Chronic Urticaria; Clinical and Epidemiological Review Study. Iran J Health Sci. 2021; 9 (1) :35-44
URL: http://jhs.mazums.ac.ir/article-1-688-en.html
Pediatric infectious diseases research center, Molecular and Cell biology Research Center , Mazandaran University of medical sciences, Sari, Iran , siamakdabaghzade@yahoo.com
Abstract:   (148 Views)
Background and purpose: Urticaria is a pruritic cutaneous disease characterized by weal and flare.  Acute and chronic urticaria affects the quality of life. Some abnormalities are associate or comorbid with urticaria. The purpose of this study was to examine comorbid conditions in patients with urticaria.
 Materials and Methods: We searched in many databases including Google Scholar, PubMed, Scopus, and Embase. Keywords were comorbid and urticarial. All full articles and the English language were included. We evaluated 500 articles that reported association or relation as comorbidity between urticarial and disorders in primary screening to be 250, 100, 80, and 70 articles in Google Scholar, PubMed, Scopus, and Embase, respectively.
 Results: Prevalence of psychiatric problem (according to SCID-1) was 60% in chronic idiopathic urticaria. Thyroid autoantibodies (anti-thyroglobulin and anti-peroxidase) were found to be positive about 5 to 15% of CU. Food allergy, allergic rhinitis, atopic dermatitis, and asthma were significantly higher in CSU. Eradication of H.pylori infection was a tendency to more rapid improvement of chronic urticaria.
Conclusion: Psychiatric disturbances, such as depression or anxiety and autoimmune thyroid disorders, were documented to be more common in chronic urticaria which should be considered as comorbidity.
Full-Text [PDF 525 kb]   (41 Downloads)    
Type of Study: Review Article | Subject: Dermatology

References
1. Zuberbier T, Aberer W, Asero R, Abdul Latiff AH, Baker D, Ballmer-Weber B, et al. The guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018;73(7):1393-414. [DOI:10.1111/all.13397] [PMID]
2. Ghaffari J, Farid Hossaini R, Rafatpanah H, Jabbari Azad F, Shahmohammadi S. Chronic urticaria in children: Etiologies, Clinical Manifestations, Diagnosis and Treatment. Journal of Pediatrics Review. 2013;1 (2) :55-68.
3. Confino-Cohen R, Chodick G, Shalev V, Leshno M, Kimhi O, Goldberg A.Chronic urticaria and autoimmunity: associations found in a large population study. Journal of Allergy and Clinical Immunology. 2012 May;129(5):1307-13. [DOI:10.1016/j.jaci.2012.01.043] [PMID]
4. Ghaffari J, Yazdani-Charati J, Zamanfar D, Sadogh A. Evaluation of the Quality of life in patients with chronic urticaria. Medical journal of Mashhad University of medical sciences. 2014; 57(4):622-8.
5. Mehrinejad SA, Jalili M, Ghaffari J. Comparison between psychological traits of patients with various atopic allergic diseases and healthy volunteers: A case-control study. Indian Journal of Allergy, Asthma and immunology. 2013; 27(1): 42-6. [DOI:10.4103/0972-6691.116613]
6. Hosseini Farahabadi S, Tavakkol- Afshari J, Ganjali R, Rafatpanah H, Ghaffari J, Farid-Hosseini R.Association between the polymorphism of TGF-beta1 gene promoter (-509C>T) and idiopathic chronic urticaria. Iranian Journal of Allergy, Asthma and Immunology. 2006;5(3):109- 13. [DOI:10.1016/j.clim.2007.03.107]
7. Ghafari J, Kosarian M, Nazari Z, Nabavi M. Relation between chronic urticaria and thyroid autoimmunity. Journal of Mazandaran University of Medical Sciences. 2008;18(63):66-72.
8. Ghaffari J, Mohammadzadeh E, Mahdavi M. Skin Prick Test with Aeroallergens in Patients with Chronic Urticaria. Journal of Babol if Medical Sciences. 2012;14 (2):66-72.
9. Ghaffari J. Prevalence of aeroallergens in skin test of asthma, allergic rhinitis, eczema and chronic urticaria patients in Iran. Journal of Mazandaran University of Medical Sciences.2012;22(87):139-51.
10. Nazari Z, Ghaffari J, Ghaffari N, Ahangarkani F. A review on hypersensitivity reactions to fungal aeroallergens in patients with allergic disorders in Iran. Current Medical Mycology. 2019;5(1):42-7. [DOI:10.18502/cmm.5.1.537] [PMID] [PMCID]
11. Ghaffari j, Farid R, Nazari Z, Jabbari Azad F.Helico bacter Pylori (HP) infection and chronic urticarial. November 2007 World Allergy Organization Journal. [DOI:10.1097/01.WOX.0000301770.37653.0c]
12. Nazari Z, Ghaffari J, Ghaffari N. Chronic urticaria associated with malignancies: A review article. Chronic Diseases Journal. 2019;7(2):128-32.
13. Ghaffari J, Khademloo M, Mohammadzadeh I, Golpoor M. Chronic urticaria: the necessity of laboratory examination. Zahedan Journal of Research in Medical Sciences.2013; 15(4): 66-8.
14. Zuberbier T, Bernstein JA. A Comparison of the United States and International Perspective on Chronic Urticaria Guidelines. Journal of Allergy and Clinical Immunology: In Practice. 2018;6(4):1144-51. [DOI:10.1016/j.jaip.2018.04.012] [PMID]
15. Ghaffari J. A review of recent treatment of urticarial in children and adults. Clinical Excellence. 2019; 8(4):1-8.
16. Khan AD, Saini S, Callen J. Chronic spontaneous urticaria: Standard management and patient education. This topic last updated, 2018. www.uptodate.com
17. Ghaffari J, Ghaffari N. Omalizumab for treatment of chronic urticaria: A review of effective dose. Pharmaceutical and Biomedical Research. 2019;5(1):1-5. [DOI:10.18502/pbr.v5i1.758]
18. Ghaffari J, Shahmohammadi S, Ashrafi H, Ranjbar A R, Ghaffari N. Omalizumab (Xolair) in Children Above 12 Years with Chronic Urticaria: A Review of Literature. Journal of Pediatrics Review. 2015;3(1):e152. [DOI:10.5812/jpr.152]
19. Valderas JM, Starfield B, Sibbald B, Salisbury C, Roland M. Defining comorbidity: implications for understanding health and health services. Annals of Family Medicine.2009;7(4):357-63. [DOI:10.1370/afm.983] [PMID] [PMCID]
20. Kolkhir P, Metz M, Altrichter S, Maurer M.Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: A systematic review. Allergy. 2017 Oct;72(10):1440-60. Chung MC, Symons C, Gillioam J. The relationship between posttraumatic stress disorder, psychiatric comorbidity, and personality traits among patients with chronic idiopathic urticaria. Comprehensive Psychiatry 2010; 51: 55-63. [DOI:10.1016/j.comppsych.2009.02.005] [PMID]
21. Chung MC, Symons C, Gilliam J, Kaminski ER.Posttraumatic stress disorder, emotional suppression and psychiatric co-morbidity in patients with chronic idiopathic urticaria: a moderated mediation analysis. Journal of Mental Health. 2018 Oct;27(5):442-9. [DOI:10.1080/09638237.2018.1437601] [PMID]
22. Gupta MA, Gupta AK.Chronic idiopathic urticaria and post-traumatic stress disorder (PTSD): an under-recognized comorbidity. Clinical Dermatology. 2012 May-Jun;30(3):351-4. [DOI:10.1016/j.clindermatol.2012.01.012] [PMID]
23. asperska-Zajac A, Brzoza Z, Rogala B. Lower serum dehydroepiandroterone sulfate concentration in chronic idiopathic urticaria: a secondary transient phenomenon? British Journal of Dermatology. 2008; 159:743-4. [DOI:10.1111/j.1365-2133.2008.08694.x] [PMID]
24. Brzoza Z, Kasperska-Zajac A, Badura-Brzoza K, et al. Decline in dehydroepiandrosterone sulfate observed in chronic urticaria is associated with psychological distress. Psychosomatic Medicine. 2008; 70:723-8. [DOI:10.1097/PSY.0b013e31817bcc8d] [PMID]
25. Hergüner S, Kiliç G, Karakoç S, Tamay Z, Tüzün U, Güler N.Levels of depression, anxiety and behavioural problems and frequency of psychiatric disorders in children with chronic idiopathic urticaria. British Journal of Dermatology. 2011 Jun;164(6):1342-7. [DOI:10.1111/j.1365-2133.2010.10138.x] [PMID]
26. Hunkin V, Chung MC.Chronic idiopathic urticaria, psychological co-morbidity and posttraumatic stress: the impact of alexithymia and repression. Psychiatric Quarterly. 2012 Dec;83(4):431-47. [DOI:10.1007/s11126-012-9213-7] [PMID]
27. Staubach P, Eckhardt-Henn A, Dechene M, Vonend A, Metz 2. M, Magerl M, et al. Quality of life in patients with chronic urticaria is differentially impaired and determined by psy-chiatric comorbidity. British Journal of Dermatology. 2006; 154: 294-8. [DOI:10.1111/j.1365-2133.2005.06976.x] [PMID]
28. Staubach P, Dechene M, Metz M, Magerl M, Siebenhaar F, Weller K, Zezula P, Eckhardt-Henn A, Maurer M.High prevalence of mental disorders and emotional distress in patients with chronic spontaneous urticaria. Acta Dermato- Venereologica. 2011 Sep;91(5):557-61. [DOI:10.2340/00015555-1109] [PMID]
29. Ozkan M, Oflaz SB, Kocaman N. Psychiatric morbidity and quality of life in patients with chronic idiopathic urticaria. Annals of Allergy, Asthma and Immunology. 2007; 99: 29-33. [DOI:10.1016/S1081-1206(10)60617-5]
30. Yang HY, Sun CC, Wu YC, Wong JD. Stress, insomnia and chronic idiopathic urticaria-a case control study. Journal of the Formosan Medical Association. 2005; 104:254-63.
31. Cornillier H, Giraudeau B, Munck S, Hacard F, Jonville-Bera AP, d'Acremont G, et al.Chronic spontaneous urticaria in children - a systematic review on interventions and comorbidities. Pediatric Allergy and Immunology. 2018 May;29(3):303-10. [DOI:10.1111/pai.12870] [PMID]
32. Konstantinou GN, Konstantinou GN. Psychiatric comorbidity in chronic urticaria patients: a systematic review and meta-analysis. Clinical and Translational Allergy. 2019;9(42):1-12. [DOI:10.1186/s13601-019-0278-3] [PMID] [PMCID]
33. Rosman Y, Hershko AY, Meir-Shafrir K, Kedem R, Lachover-Roth I, Mekori YA, et al. Characterization of chronic urticaria and associated conditions in a large population of adolescents. Journal of the American Academy of Dermatology. 2019 Jul;81(1):129-35. [DOI:10.1016/j.jaad.2019.02.034] [PMID]
34. Kim BR, Yang S, Choi JW, Choi CW, Youn SW. Epidemiology and comorbidities of patients with chronic urticaria in Korea: A nationwide population-based study. Journal of Dermatology. 2018 Jan;45(1):10-16. [DOI:10.1111/1346-8138.14075] [PMID]
35. Zazzali JL, Broder MS, Chang E, Chiu MW, Hogan DJ. Cost, utilization, and patterns of medication use associated with chronic idiopathic urticaria. Annals of Allergy, Asthma and Immunology. 2012; 108: 98-102. [DOI:10.1016/j.anai.2011.10.018] [PMID]
36. Thomsen SF, Pritzier EC, Anderson CD et al. Chronic urticaria in the real-life clinical practice setting in Sweden, Norway and Denmark: baseline results from the non-interventional multicentre AWARE study. Journal of the European Academy of Dermatology Venereology. 2017; 31: 1048-55. [DOI:10.1111/jdv.14210] [PMID]
37. Chen YJ, Wu CY, Shen JL, Chen TT, Chang YT. Cancer risk in patients with chronic urticaria: a population-based cohort study. Archives of Dermatology. 2012; 148: 103-8. [DOI:10.1001/archdermatol.2011.682] [PMID]
38. 39.Lapi F, Cassano N, Pegoraro V et al. Epidemiology of chronic spontaneous urticaria: results from a nationwide, population-based study in Italy. British Journal of Dermatology. 2016;174:996-1004. [DOI:10.1111/bjd.14470] [PMID]
39. Kolkhir P, Pogorelov D, Olisova O, Maurer M.Comorbidity and pathogenic links of chronic spontaneous urticaria and systemic lupus erythematosus--a systematic review. Clinical and Experimental Allergy. 2016 Feb;46(2):275-87. [DOI:10.1111/cea.12673] [PMID]
40. Dreskin SC, Andrews KY. The thyroid and urticaria. Current Opinion in Allergy and Clinical Immunology. 2005; 5: 408-12. [DOI:10.1097/01.all.0000182546.83465.5a] [PMID]
41. Gonzalez-Diaz SN, Sanchez-Borges M, Rangel-Gonzalez DM, Guzman-Avilan RI, Canseco-Villarreal JI, Arias-Cruz A. Chronic urticaria and thyroid pathology. World Allergy Organization Journal. 2020;13(3):100101. [DOI:10.1016/j.waojou.2020.100101] [PMID] [PMCID]
42. Hosseinzadeh Attar M, Merk HF, Kotliar K, Wurpts G, Röseler S, Moll-Slodowy S, et al.The CD63 basophil activation test as a diagnostic tool for assessing autoimmunity in patients with chronic spontaneous urticaria. European Journal of Dermatology. 2019 Dec 1;29(6):614-8. [DOI:10.1684/ejd.2019.3680] [PMID]
43. Najafipour M, Zareizadeh M, Najafipour F. Relationship between Chronic urticaria and autoimmune thyroid disease. Journal of Advanced Pharmaceutical Technology and Research. 2018;9(4):158-61. [DOI:10.4103/japtr.JAPTR_342_18] [PMID] [PMCID]
44. Kasumagic-Halilovic E, Beslic N, Ovcina-Kurtovic N. Thyroid Autoimmunity in Patients with Chronic Urticaria. Medical Archives. 2017;71(1):29-31. [DOI:10.5455/medarh.2017.71.29-31] [PMID] [PMCID]
45. Nebiolo F, Bergia R, Bommarito L, Bugiani M. Effect of arterial hypertension on chronic urticaria duration. Annals of Allergy, Asthma and Immunology. 2009; 103: 407-10. [DOI:10.1016/S1081-1206(10)60360-2]
46. Chang HW, Cheng HM, Yeng HR, Hsu CY, Lee YC, Chiang JH, Sun MF. Association between chronic idiopathic urticaria and hypertension: A population-based retrospective cohort study. Annals of Allergy, Asthma and Immunology. 2016; 116: 554-8. [DOI:10.1016/j.anai.2016.04.001] [PMID]
47. Kaplan AP, Greaves M. Pathogenesis of chronic urticaria. Clinical and Experimental Allergy. 2009; 39:777-87. [DOI:10.1111/j.1365-2222.2009.03256.x] [PMID]
48. Ferrer M. Immunological events in chronic spontaneous urticaria. Clinical and Translational Allergy. 2015; 5: 30. [DOI:10.1186/s13601-015-0074-7] [PMID] [PMCID]
49. Młynek A, Magerl M, Hanna M, Lhachimi S, Baiardini I, Canonica GW, Brzoza Z, Kasperska-Zajac A, Rogala B, Zalewska-Janowska A, Zuberbier T, Maurer M. The German version of the Chronic Urticaria Quality-of-Life Questionnaire: factor analysis, validation, and initial clinical findings. Allergy. 2009; 64: 927-36. [DOI:10.1111/j.1398-9995.2008.01920.x] [PMID]
50. Pan XF, Gu JQ, Shan ZY.The prevalence of thyroid autoimmunity in patients with urticaria: a systematic review and meta-analysis. Endocrine. 2015 Apr;48(3):804-10. [DOI:10.1007/s12020-014-0367-y] [PMID]
51. Bagnasco M, Minciullo PL, Saraceno GS, Gangemi S, Benvenga S. Urticaria and thyroid autoimmunity. Thyroid. 2011 Apr;21(4):401-10. [DOI:10.1089/thy.2010.0103] [PMID]
52. Pasaoglu G, Bavbek S, Tugcu H, Abadoglu O, Misirligil Z: Psychological status of patients with chronic urticaria. Journal of Dermatology. 2006; 33: 765-71. [DOI:10.1111/j.1346-8138.2006.00178.x] [PMID]
53. Engin B, Uguz F, Yilmaz E, Özdemir M, Mevlitoglu I. The levels of depression, anxiety and quality of life in patients with chronic idiopathic urticaria. Journal of the European Academy of Dermatology and Venereology. 2008;22: 36-40.
54. Uguz F, Engin B, Yilmaz E. Axis I and Aixis II diagnoses in patients with chronic idiopathic Urticaria. Journal of Psychosomatic Research. 2008; 64: 225-9. [DOI:10.1016/j.jpsychores.2007.08.006] [PMID]
55. Ghazanfar MN, Kibsgaard L, Thomsen SF, Vestergaard C. Risk of comorbidities in patients diagnosed with chronic urticaria: A nationwide registry-study. World Allergy Organization Journal. 2020;13(1):100097. [DOI:10.1016/j.waojou.2019.100097] [PMID] [PMCID]
56. Kolkhir P, Pereverzina N, Olisova O, Maurer M.Comorbidity of viral hepatitis and chronic spontaneous urticaria: A systematic review. Allergy. 2018 Oct;73(10):1946-53. [DOI:10.1111/all.13482] [PMID]
57. Shakouri A, Compalati E, Lang DM, Khan DA. Effectiveness of Helicobacter pylori eradication in chronic urticaria: evidence-based analysis using the Grading of Recommendations Assessment, Development, and Evaluation system. Current Opinion Allergy and Clinical Immunology. 2010; 10:362-9. [DOI:10.1097/ACI.0b013e32833c79d7] [PMID]
58. Kim HJ, Kim YJ, Lee HJ, Hong JY, Park AY, Chung EH, et al.Systematic review and meta-analysis: Effect of Helicobacter pylori eradication on chronic spontaneous urticaria. Helicobacter. 2019;24 (6):e12661. [DOI:10.1111/hel.12661] [PMCID]
59. Gereige J, Chen CH, Guenechea-Sola M. A Systematic Review of Helicobacter pylori Eradication and its Effect on Chronic Idiopathic Urticaria. February 2020;145(2); Supplement, Page AB202. [DOI:10.1016/j.jaci.2019.12.304]
60. Al-Naemi S R, Al-Mirani B K, Hussein N R. Association of Chronic Urticaria with Helicobacter pylori Infection in Duhok City, Kurdistan Region of Iraq, Journal of Skin and Stem Cell. Online ahead of Print; 5(4): e92774. doi: 10.5812/jssc.92774. [DOI:10.5812/jssc.92774]
61. Essrani R, Sullivan M, Shah H. Chronic Urticaria Associated with Helicobacter pylori. Cureus. 2019;11(4): e4528. [DOI:10.7759/cureus.4528]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


© 2021 All Rights Reserved | Iranian Journal of Health Sciences

Designed & Developed by : Yektaweb