Volume 10, Issue 2 (Spring 2022)                   Iran J Health Sci 2022, 10(2): 48-57 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Babaei M, Abdi A, Mehrabani J, Abbassi Daloii A. The Effect of Aerobic Training and Spirulina on Nesfatin-1 and Peptide YY in Overweight Elderly Men: A randomized trial. Iran J Health Sci. 2022; 10 (2) :48-57
URL: http://jhs.mazums.ac.ir/article-1-799-en.html
Azad University , a.abdi58@gmail.com
Abstract:   (248 Views)
Background and purpose: Research has shown that aging affects appetite and energy intake. The aim of this study was to investigate the protective effect of aerobic training (AT) and spirulina (SP) on Nesfatin-1 and Peptide YY (PYY) in overweight elderly men.
Materials and Methods: In this clinical trial study, 32 overweight elderly men (age 57.50±4.84 years, Body mass index: BMI 26.90±2.85 kg/m2) in public and administrative centers of Bandar-e-Anzali were selected and randomly divided into four groups including Overweight (OW), Overweight-Aerobic Training (OWAT), Overweight-Spirulina (OWSP), and Overweight-Aerobic Training -Spirulina (OWATSP). AT, including running on treadmill was performed three sessions per week with intensity of 70 - 85% of maximum heart rate for eight weeks. The groups of OWSP and OWATSP were provided two 500 mg SP tablets daily in the morning and evening. Serum Nesfatin-1 and PYY levels were measured using the kit and ELISA method. Data were tested using independent samples t-test and ANCOVA at a significance level of p <0.05
Results: Mean weight and BMI in the groups of aerobic exercise, spirulina and exercise- spirulina decreased significantly (P<0.05). The results showed that exercise, spirulina and exercise-spirulina caused a significant increase in Nesfatin-1 and Peptide YY compared to the pretest and control group (P=0.001). Also, the Nesfatin-1 and Peptide YY level of the exercise- spirulina group was significantly higher than the spirulina group (P=0.003).  
Conclusion: AT intervention and daily intake of SP supplement were associated with increase in hormones affecting appetite. It was then recommended that overweight and obese elderly people use this effective combination strategy for its benefits.

Full-Text [PDF 547 kb]   (152 Downloads)    
Type of Study: Original Article | Subject: Nutrition

1. Johnson KO, Shannon OM, Matu J, Holliday A, Ispoglou T, Deighton K. Differences in circulating appetite-related hormone concentrations between younger and older adults: A systematic review and meta-analysis. Aging clinical and experimental research. 2020; 32(7):1233-44. [DOI:10.1007/s40520-019-01292-6] [PMID] [PMCID]
2. Murphy KG, Bloom SR. Gut hormones and the regulation of energy homeostasis. Nature. 2006; 444(7121):854-9. [DOI:10.1038/nature05484] [PMID]
3. Deniz R, Gurates B, Aydin S, Celik H, Sahin I, Baykus Y, et al. Nesfatin-1 and other hormone alterations in polycystic ovary syndrome. Endocrine. 2012; 42(3):694-9. [DOI:10.1007/s12020-012-9638-7] [PMID]
4. Aydin S. Multi-functional peptide hormone NUCB2/nesfatin-1. Endocrine. 2013; 44(2):312-25. [DOI:10.1007/s12020-013-9923-0] [PMID]
5. Oh S, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature. 2006; 443(7112):709-12. [DOI:10.1038/nature05162] [PMID]
6. Karra E, Chandarana K, Batterham RL. The role of peptide YY in appetite regulation and obesity. Wiley Online Library; 2009 15; 587(1):19-25. [DOI:10.1113/jphysiol.2008.164269] [PMID] [PMCID]
7. Batterham RL, Bloom SR. The gut hormone peptide YY regulates appetite. Annals of the New York Academy of Sciences. 2003; 994(1):162-8. [DOI:10.1111/j.1749-6632.2003.tb03176.x] [PMID]
8. Guo Y, Ma L, Enriori PJ, Koska J, Franks PW, Brookshire T, et al. Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans. Obesity. 2006; 14(9):1562-70. [DOI:10.1038/oby.2006.180] [PMID]
9. Cooper JA. Factors affecting circulating levels of peptide YY in humans: a comprehensive review. Nutrition research reviews. 2014; 27(1):186-97. [DOI:10.1017/S0954422414000109] [PMID]
10. Decaria J, Sharp C, Petrella R. Scoping review report: obesity in older adults. International journal of obesity. 2012; 36(9):1141-50. [DOI:10.1038/ijo.2012.29] [PMID]
11. Faraji H, Dabagh Nikokheslat S. The effect of concurrent training on plasma Nesfatin, Resistin, Visfatin and peptide YY levels in obese women. Metabolic and Exercise. 2016; 6(1):19-31.
12. Amanat S, Sinaei E, Panji M, MohammadporHodki R, Bagheri-Hosseinabadi Z, Asadimehr H, et al. A randomized controlled trial on the effects of 12 weeks of aerobic, resistance, and combined exercises training on the serum levels of nesfatin-1, irisin-1 and HOMA-IR. Frontiers in Physiology. 2020; 11. [DOI:10.3389/fphys.2020.562895] [PMID] [PMCID]
13. UĞRAŞ S, ÖZÇELIK O. Impact of exercise induced skeletal muscle strain on energy regulatory hormones of irisin and nesfatin-1 in sedentary males. Turk Hijyen ve Deneysel Biyoloji Dergisi. 2020; 77(2): 227-232 [DOI:10.5505/TurkHijyen.2020.91328]
14. Scheid JL, De Souza MJ, Leidy HJ, Williams NI. Ghrelin but not peptide YY is related to change in body weight and energy availability. Medicine and science in sports and exercise. 2011; 43(11):2063-71. [DOI:10.1249/MSS.0b013e31821e52ab] [PMID]
15. Lupatini AL, Colla LM, Canan C, Colla E. Potential application of microalga Spirulina platensis as a protein source. Journal of the Science of Food and Agriculture. 2017; 97(3):724-32. [DOI:10.1002/jsfa.7987] [PMID]
16. Fujimoto M, Tsuneyama K, Fujimoto T, Selmi C, Gershwin ME, Shimada Y. Spirulina improves non-alcoholic steatohepatitis, visceral fat macrophage aggregation, and serum leptin in a mouse model of metabolic syndrome. Digestive and liver disease. 2012; 44(9):767-74. [DOI:10.1016/j.dld.2012.02.002] [PMID]
17. Peto R, Whitlock G, Jha P. Effects of obesity and smoking on US life expectancy. The New England journal of medicine. 2010; 362(9):855-6; author reply 6. [DOI:10.1056/NEJMc1000079] [PMID]
18. Eskandari M, Pournemati P, Hooshmand Moghadam B, Norouzi J. The Interactive Effect of Aerobic Exercise and Supplementation of Blue-Algae (Spirulina) on Anthropometric Indexes and Cardiovascular Risk Factors in Diabetic Men. Sadra Medical Journal. 2019; 8(1):51-62.
19. Villareal DT, Aguirre L, Gurney AB, Waters DL, Sinacore DR, Colombo E, et al. Aerobic or resistance exercise, or both, in dieting obese older adults. New England Journal of Medicine. 2017; 376(20):1943-55. [DOI:10.1056/NEJMoa1616338] [PMID] [PMCID]
20. Price CJ, Samson WK, Ferguson AV. Nesfatin-1 inhibits NPY neurons in the arcuate nucleus. Brain research. 2008; 1230:99-106. [DOI:10.1016/j.brainres.2008.06.084] [PMID] [PMCID]
21. Ramanjaneya M, Chen J, Brown JE, Tripathi G, Hallschmid M, Patel S, et al. Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity. Endocrinology. 2010; 151(7):3169-80. [DOI:10.1210/en.2009-1358] [PMID]
22. Dore R, Levata L, Lehnert H, Schulz C. Nesfatin-1: functions and physiology of a novel regulatory peptide. J Endocrinol. 2017; 232(1):R45-R65. [DOI:10.1530/JOE-16-0361] [PMID]
23. Taji Tabas A, Mogharnasi M. The effect of 10 week resistance exercise training on serum levels of nesfatin-1 and insulin resistance index in woman with type 2 diabetes. Iranian journal of Diabetes and Metabolism. 2015; 14(3):179-88.
24. Deighton K, Barry R, Connon CE, Stensel DJ. Appetite, gut hormone and energy intake responses to low volume sprint interval and traditional endurance exercise. European journal of applied physiology. 2013; 113(5):1147-56. [DOI:10.1007/s00421-012-2535-1] [PMID]
25. Hazell TJ, Islam H, Townsend LK, Schmale MS, Copeland JL. Effects of exercise intensity on plasma concentrations of appetite-regulating hormones: Potential mechanisms. Appetite. 2016; 98:80-8. [DOI:10.1016/j.appet.2015.12.016] [PMID]
26. Brechet S, Plaisancié P, Dumoulin V, Chayvialle J, Cuber J, Claustre J. Involvement of beta1-and beta2-but not beta3-adrenoceptor activation in adrenergic PYY secretion from the isolated colon. Journal of endocrinology. 2001; 168(1):177-83. [DOI:10.1677/joe.0.1680177] [PMID]
27. Crabtree DR, Blannin AK. Effects of exercise in the cold on Ghrelin, PYY, and food intake in overweight adults. Medicine and science in sports and exercise. 2015; 47(1):49-57. [DOI:10.1249/MSS.0000000000000391] [PMID]
28. Suzuki K, Simpson KA, Minnion JS, Shillito JC, Bloom SR. The role of gut hormones and the hypothalamus in appetite regulation. Endocrine journal. 2010; 57(5):359-72. [DOI:10.1507/endocrj.K10E-077] [PMID]
29. Schubert MM, Sabapathy S, Leveritt M, Desbrow B. Acute exercise and hormones related to appetite regulation: a meta-analysis. Sports medicine. 2014; 44(3):387-403. [DOI:10.1007/s40279-013-0120-3] [PMID]
30. Mokhtari M, Daryanoosh F. The effect of 12 weeks resistance exercise on plasma levels of Apelin-12, Nesfatin-1 and resting heart rate in hypertensive elderly women. Medical journal of mashhad university of medical sciences. 2015; 58(6):330-7.
31. Kanaley JA, Heden TD, Liu Y, Whaley-Connell AT, Chockalingam A, Dellsperger KC, et al. Short-term aerobic exercise training increases postprandial pancreatic polypeptide but not peptide YY concentrations in obese individuals. International journal of obesity. 2014; 38(2):266-71. [DOI:10.1038/ijo.2013.84] [PMID] [PMCID]
32. El-Sayed E-SM, Hikal M, Abo El-Khair B, El-Ghobashy R, El-Assar A. Hypoglycemic and Hypolipidemic Effects of Spirulina Platensis, Phycocyanin, Phycocyanopeptide and Phycocyanobilin on Male Diabetic Rats. Arab Universities Journal of Agricultural Sciences. 2018; 26(Special issue (2A)):1121-34. [DOI:10.21608/ajs.2018.28365]
33. Zeinalian R, Farhangi MA, Shariat A, Saghafi-Asl M. The effects of Spirulina Platensis on anthropometric indices, appetite, lipid profile and serum vascular endothelial growth factor in obese individuals: a randomized double blinded placebo controlled trial. BMC complementary and alternative medicine. 2017; 17(1):1-8. [DOI:10.1186/s12906-017-1670-y] [PMID] [PMCID]
34. Golestani F, Mogharnasi M, Erfani-Far M, Abtahi-Eivari SH. The effects of spirulina under high-intensity interval training on levels of nesfatin-1, omentin-1, and lipid profiles in overweight and obese females: A randomized, controlled, single-blind trial. Journal of Research in Medical Sciences, Isfahan University of Medical Sciences. 2021; 26:10. [DOI:10.4103/jrms.JRMS_1317_20] [PMID] [PMCID]

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | Iranian Journal of Health Sciences

Designed & Developed by : Yektaweb